S-Adenosylmethionine-Dependent Methyltransferases

Résumé

It was in the 1940s that Du Vigneaud and colleagues found that a substantial fraction of the methyl groups in cell metabolites derived from methionine, and in the 1950s [10] Cantoni and colleagues found that the actual methyl donor is the ATP-activated form of methionine, S-adenosyl-L-methionine (AdoMet).